Mass Effect: Ghosts
Like the ancient human city of Troy, Ilos is a world known only through second-hand sources. References to Ilos have been found at several other Prothean ruins, though direct study of the world is unlikely to occur.
Ilos lies in a remote area of the Terminus Systems only accessible by the legendary Mu Relay. Four thousand years ago, the Mu Relay was knocked out of position by a supernova and lost. Since then, Ilos and its cluster have been inaccessible.
Occasionally, a university will organize an expedition to chart a route to Ilos using conventional FTL drive. These never get beyond the planning stages due to the distance and danger. The journey could take years or decades, passing through the hostile Terminus Systems and dozens of unexplored systems.